Cross-priming of CD8+ T cells by viral and tumor antigens is a robust phenomenon Academic Article uri icon


  • "Cross-priming" refers to the activation of naive CD8+ T cells by antigen-presenting cells that have acquired nominal antigens from another cell. The biological relevance of cross-priming of CD8+ T cells has recently been challenged (Zinkernagel, R. M., Eur. J. Immunol. 2002. 32: 2385-2392), on the basis that responses are weak or poorly quantitated, and the determinants recognized are undefined. Here we show that cross-priming is a robust process that elicits vigorous primary responses to multiple peptides in two well-defined systems. Our findings support the relevance of cross-priming in CD8+ T cell responses to viruses and tumor cells, and demonstrate that cross-priming elicits CD8+ T cells to determinants generated by the endogenous processing pathway.


  • Chen, Weisan
  • Masterman, Kelly-Anne
  • Basta, Sameh
  • Mansour Haeryfar, SM
  • Dimopoulos, Nektaria
  • Knowles, Barbara
  • Bennink, Jack R
  • Yewdell, Jonathan W

publication date

  • January 2004