People with schizophrenia and depression have a low omega-3 index Academic Article uri icon

abstract

  • Cardiovascular disease (CVD) is higher in people with mental illness and is associated with a 30 year higher mortality rate in this population. Erythrocyte docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (omega-3 index)≤4% is a marker for increased mortality risk from CVD while >8% is protective. Omega-3 polyunsaturated fatty acids are also important for brain function and may ameliorate symptoms of mental illness. We investigated the erythrocyte omega-3 index in people with mental illness. One hundred and thirty adults aged 18-65 years (32.6% male) with schizophrenia (n=14) and depression (n=116) provided blood samples and completed physiological assessments and questionnaires. Both populations had risk factors for metabolic syndrome and CVD. The average omega-3 index was 3.95% (SD=1.06), compared to an estimated 5% in the Australian population. These data indicate an unfavourable omega-3 profile in people with mental illness that could contribute to higher CVD risk.

authors

  • Parletta, N
  • Zarnowiecki, D
  • Cho, J
  • Wilson, A
  • Procter, N
  • Gordon, A
  • Bogomolova, S
  • O'Dea, K
  • Strachan, J
  • Ballestrin, M
  • Champion, A
  • Meyer, BJ

publication date

  • 2016