Dietary inflammatory index and incidence of cardiovascular disease in the PREDIMED study Academic Article uri icon

abstract

  • Previous studies have reported an association between a more pro-inflammatory diet profile and various chronic metabolic diseases. The Dietary Inflammatory Index (DII) was used to assess the inflammatory potential of nutrients and foods in the context of a dietary pattern. We prospectively examined the association between the DII and the incidence of cardiovascular disease (CVD: myocardial infarction, stroke or cardiovascular death) in the PREDIMED (Prevención con Dieta Mediterránea) study including 7216 high-risk participants. The DII was computed based on a validated 137-item food frequency questionnaire. Multivariate-adjusted hazard ratios (HR) and 95% confidence intervals of CVD risk were computed across quartiles of the DII where the lowest (most anti-inflammatory) quartile is the referent. Risk increased across the quartiles (i.e., with increasing inflammatory potential): HR(quartile2) = 1.42 (95%CI = 0.97-2.09); HR(quartile3) = 1.85 (1.27-2.71); and HR(quartile4) = 1.73 (1.15-2.60). When fit as continuous the multiple-adjusted hazard ratio for each additional standard deviation of the DII was 1.22 (1.06-1.40). Our results provide direct prospective evidence that a pro-inflammatory diet is associated with a higher risk of cardiovascular clinical events.

authors

  • Garcia-Arellano, A
  • Ramallal, R
  • Ruiz-Canela, M
  • Salas-Salvadó, J
  • Corella, D
  • Shivappa, N
  • Schröder, H
  • Hébert, JR
  • Ros, E
  • Gómez-Garcia, E
  • Estruch, R
  • Lapetra, J
  • Arós, F
  • Fiol, M
  • Serra-Majem, L
  • Pintó, X
  • Babio, N
  • González, JI
  • Fitó, M
  • Alfredo Martínez, J
  • Martínez-González, MA
  • Buil-Cosiales, P
  • Diez-Espino, J
  • Toledo, E
  • Sanjulian, B
  • Marti, A
  • Basterra-Gortari, FJ
  • Estremera-Urabayen, V
  • Sola-Larraza, A
  • Barcena-Amigo, F
  • Oreja-Arrayago, C
  • Serrano-Martínez, M
  • Lasanta-Saez, MJ
  • Quintana-Pedraza, L
  • Amezcueta-Goñi, C
  • Cia-Lecumberri, P
  • Artal-Moneva, F
  • Esparza-López, JM
  • Figuerido-Garmendia, E
  • Ruiz-Millan, H
  • Oses-Primo, R
  • Tabar-Sarrias, JA
  • Fernandez-Urzainqui, L
  • Ariz-Arnedo, MJ
  • Forcen-Alonso, T
  • Pascual-Pascual, P
  • Garces, ML
  • Extremera, V
  • Garcia-Perez, L
  • Basora, J
  • Gonzalez, N
  • Molina, C
  • Marquez, F
  • Martínez, P
  • Ibarrola, N
  • Sorli, M
  • García Roselló, J
  • Castro, A
  • Martin, F
  • Tort, N
  • Isach, A
  • Guasch-Ferre, M
  • Baldrich, M
  • Cabre, JJ
  • Mestres, G
  • Paris, F
  • Llauradó, M
  • Pedret, R
  • Basells, J
  • Vizcaino, J

publication date

  • 2015

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