Low-fat dairy products and blood pressure: follow-up of 2290 older persons at high cardiovascular risk participating in the PREDIMED study Academic Article uri icon


  • High blood pressure (BP) has been ranked as the most important risk factor worldwide regarding attributable deaths. Dietary habits are major determinants of BP. Among them, frequent intake of low-fat dairy products may protect against hypertension. Our aim was to assess the relationship between low-fat dairy product intake and BP levels and their changes after 12-month follow-up in a cohort of asymptomatic older persons at high cardiovascular risk recruited into a large-scale trial assessing the effects of Mediterranean diets on cardiovascular outcomes. Data from 2290 participants, including 1845 with hypertension, were available for analyses. Dairy products were not a specific part of the intervention; thus, data were analysed as an observational cohort. Dietary information was collected with validated semi-quantitative FFQ and trained personnel measured BP. To assess BP changes, we undertook cross-sectional analyses at baseline and at the end of follow-up and longitudinal analyses. A statistically significant inverse association between low-fat dairy product intake and systolic BP was observed for the 12-month longitudinal analysis. In the longitudinal analysis, the adjusted systolic and diastolic BP were significantly lower in the highest quintile of low-fat dairy product intake ( − 4·2 (95% CI − 6·9, − 1·4) and − 1·8 (95% CI − 3·2, − 0·4) mmHg respectively), whereas the point estimates for the difference in diastolic BP indicated a modest non-significant inverse association. Intake of low-fat dairy products was inversely associated with BP in an older population at high cardiovascular risk, suggesting a possible protective effect against hypertension.


  • Martinez-Gonzalez, Miguel
  • Toledo, Estefanía
  • Delgado-Rodríguez, Miguel
  • Estruch, Ramón
  • Salas-Salvadó, Jordi
  • Corella, Dolores
  • Gomez-Gracia, Enrique
  • Fiol, Miquel
  • Lamuela-Raventós, Rosa M
  • Schröder, Helmut
  • Arós, Fernando
  • Ros, Emilio
  • Ruíz-Gutiérrez, Valentina
  • Lapetra, Jose
  • Conde-Herrera, Manuel
  • Sáez, Guillermo
  • Vinyoles, Ernest
  • Martínez-González, Miguel A

publication date

  • January 1, 2009