Cutaneous Signet Ring Cell Carcinoma Academic Article uri icon


  • Primary cutaneous signet-ring cell carcinoma (CSRCC) is a very unusual but distinctive clinicopathologic entity. It is defined as a diffuse malignant epithelial neoplasia localized in dermis and subcutis without epidermal involvement, showing variable amounts of signet ring cells, without evidence of a visceral adenocarcinoma. We report a case of CSRCC in a 70-year-old man along with its histologic and ultrastructural characteristics, and review of previous cases. We describe their main diagnostic features and discuss its wide differential diagnosis.


  • Martinez-Gonzalez, Miguel
  • González-Lois, Carmen
  • Rodríguez-Peralto, José Luis
  • Serrano-Pardo, Rosario
  • Martínez-González, Miguel Angel
  • López-Ríos, Fernando

publication date

  • August 2001