Fever of Unknown Origin in a Patient with Common Variable Immunodeficiency Associated with Multisystemic Granulomatous Disease Academic Article uri icon


  • Non-caseating epithelioid granulomas have been described in a small number of patients with common variable immunodeficiency (CVID). We report a 26-year-old woman diagnosed with CVID nine years earlier, who developed non-caseating granulomas in the liver, bone marrow and skin. She was referred to our department for a fever of more than one year duration without apparent focus. Extensive search for underlying malignancy or occult infection was unremarkable. Empirical treatment with prednisone was begun and the patient showed a marked improvement. The literature on the association between CVID and non-caseating granulomatous disease, and the differential diagnosis of hepatic granulomas as a cause of fever of unknown origin, is also reviewed.


  • Martinez-Gonzalez, Miguel
  • Fernández-Ruiz, Mario
  • Guerra-Vales, Juan-Manuel
  • Francisco-Javier, Castelbón-Fernández
  • Yolanda, Rodriguez-Gil
  • Miguel-íngel, Martánez-GonzÁlez
  • Cristina, Garfia-Castillo
  • Jesús, Ruiz-Contreras

publication date

  • 2007