The interplay between the fat mass- and obesity-associated (
FTO) gene variants and diet has been implicated in the development of obesity. The aim of the present analysis was to investigate associations between FTOgenotype, dietary intakes and anthropometrics among European adults. Participants in the Food4Me randomised controlled trial were genotyped for FTOgenotype (rs9939609) and their dietary intakes, and diet quality scores (Healthy Eating Index and PREDIMED-based Mediterranean diet score) were estimated from FFQ. Relationships between FTOgenotype, diet and anthropometrics (weight, waist circumference (WC) and BMI) were evaluated at baseline. European adults with the FTOrisk genotype had greater WC ( AA v. TT: +1·4 cm; P=0·003) and BMI (+0·9 kg/m2; P=0·001) than individuals with no risk alleles. Subjects with the lowest fried food consumption and two copies of the FTOrisk variant had on average 1·4 kg/m2 greater BMI ( Ptrend=0·028) and 3·1 cm greater WC ( Ptrend=0·045) compared with individuals with no copies of the risk allele and with the lowest fried food consumption. However, there was no evidence of interactions between FTOgenotype and dietary intakes on BMI and WC, and thus further research is required to confirm or refute these findings.