Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios Academic Article uri icon

abstract

  • Genetic variability in the FADS1-FADS2 gene cluster [encoding delta-5 (D5D) and delta-6 (D6D) desaturases] has been associated with plasma long-chain PUFA (LCPUFA) and lipid levels in adults. To better understand these relationships, we further characterized the association between FADS1-FADS2 genetic variability and D5D and D6D activities in adolescents. Thirteen single nucleotide polymorphisms (SNPs) were genotyped in 1,144 European adolescents (mean +/- SD age: 14.7 +/- 1.4 y). Serum phospholipid fatty acid levels were analyzed using gas chromatography. D5D and D6D activities were estimated from the C20:4n-6/C20:3n-6 and C20:3n-6/C18:2n-6 ratios, respectively. Minor alleles of nine SNPs were associated with higher 18:2n-6 levels (1.9E-18

authors

  • Bokor, Szilvia
  • Dumont, Julie
  • Spinneker, Andre
  • Gonzalez-Gross, Marcela
  • Nova, Esther
  • Widhalm, Kurt
  • Moschonis, George
  • Stehle, Peter
  • Amouyel, Philippe
  • De Henauw, Stefaan
  • Molnàr, Dènes
  • Moreno, Luis A
  • Meirhaeghe, Aline
  • Dallongeville, Jean

publication date

  • August 2010