Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study Academic Article uri icon

abstract

  • BACKGROUND AND AIMS:Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. METHODS AND RESULTS:A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. RESULTS:Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. CONCLUSIONS:Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently.

authors

  • González-Gil, EM
  • Cadenas-Sanchez, C
  • Santabárbara, J
  • Bueno-Lozano, G
  • Iglesia, I
  • González-Gross, M
  • Molnar, D
  • Gottrand, F
  • De Henauw, S
  • Kafatos, A
  • Widhalm, K
  • Manios, Y
  • Siani, A
  • Amaro-Gahete, F
  • Rupérez, AI
  • Cañada, D
  • Censi, L
  • Kersting, M
  • Dallongeville, J
  • Marcos, A
  • Ortega, FB
  • Moreno, LA
  • Moreno, LA
  • Gottrand, F
  • De Henauw, S
  • González-Gross, M
  • Gilbert, C
  • Kafatos, A
  • Libersa, C
  • Castelló, S
  • Kersting, M
  • Sjöstrom, M
  • Molnár, D
  • Dallongeville, J
  • Hall, G
  • Maes, L
  • Scalfi, L
  • Meléndez, P
  • Fleta, J
  • Casajús, JA
  • Rodríguez, G
  • Tomás, C
  • Mesana, MI
  • Vicente-Rodríguez, G
  • Villarroya, A
  • Gil, CM
  • Ara, I
  • Alvira, JF
  • Bueno, G
  • Lázaro, A
  • Bueno, O
  • León, JF
  • Garagorri, J Ma
  • Bueno, M
  • Labayen, I
  • Iglesia, I
  • Bel Serrat, S
  • Gracia Marco, LA
  • Mouratidou, T
  • Santaliestra-Pasías, A
  • González-Gil, EM
  • De Miguel-Etayo, P
  • Julián Almárcegui, C
  • Miguel-Berges, M
  • Iguacel, I
  • Marcos, A
  • Wärnberg, J
  • Nova, E
  • Gómez, S
  • Díaz, LE
  • Romeo, J
  • Veses, A
  • Zapatera, B
  • Pozo, T
  • Martínez, D
  • Beghin, L
  • Gottrand, F
  • Iliescu, C
  • Von Berlepsch, J
  • Sichert-Hellert, W
  • Koeppen, E
  • Molnar, D
  • Erhardt, E
  • Csernus, K
  • Török, K
  • Bokor, S
  • Angster
  • Nagy, E
  • Kovács, O
  • Répasi, J
  • Codrington, C
  • Plada, M
  • Papadaki, A
  • Sarri, K
  • Viskadourou, A
  • Hatzis, C
  • Kiriakakis, M
  • Tsibinos, G
  • Vardavas, C
  • Sbokos, M
  • Protoyeraki, E
  • Fasoulaki, M
  • Stehle, P
  • Pietrzik, K
  • Breidenassel, C
  • Spinneker, A
  • Al-Tahan, J
  • Segoviano, M
  • Berchtold, A
  • Bierschbach, C
  • Blatzheim, E
  • Schuch, A
  • Pickert, P
  • Castillo, MJ
  • Gutiérrez, Á
  • Ortega, FB
  • Ruiz, JR
  • Artero, EG
  • España, V
  • Jiménez-Pavón, D
  • Chillón, P
  • Sánchez-Muñoz, C
  • Cuenca, M
  • Arcella, D
  • Azzini, E
  • Barrison, E
  • Bevilacqua, N
  • Buonocore, P
  • Catasta, G
  • Censi, L
  • Ciarapica, D
  • D'Acapito, P
  • Ferrari, M
  • Galfo, M
  • Le Donne, C
  • Leclercq, C
  • Maiani, G
  • Mauro, B
  • Mistura, L
  • Pasquali, A
  • Piccinelli, R
  • Polito, A
  • Roccaldo, R
  • Spada, R
  • Sette, S
  • Zaccaria, M
  • Vitaglione, P
  • Montagnese, C
  • De Bourdeaudhuij, I
  • De Vriendt, T
  • Matthys, C
  • Vereecken, C
  • de Maeyer, M
  • Ottevaere, C
  • Huybrechts, I
  • Widhalm, K
  • Phillipp, K
  • Dietrich, S
  • Widhalm, K
  • Phillipp, K
  • Dietrich, S
  • Manios, Y
  • Grammatikaki, E
  • Bouloubasi, Z
  • Cook, TL
  • Eleutheriou, S
  • Consta, O
  • Moschonis, G
  • Katsaroli, I
  • Kraniou, G
  • Papoutsou, S
  • Keke, D
  • Petraki, I
  • Bellou, E
  • Tanagra, S
  • Kallianoti, K
  • Argyropoulou, D
  • Tsikrika, S
  • Karaiskos, C
  • Meirhaeghe, A
  • Meirhaeghe, A
  • Ortega, FB
  • Hagströmer, M
  • Wennlöf, AH
  • Hallström, L
  • Patterson, E
  • Kwak, L
  • Rizzo, N
  • Sánchez-Molero, J
  • Picó, E
  • Navarro, M
  • Viadel, B
  • Carreres, JE
  • Merino, G
  • Sanjuán, R
  • Lorente, M
  • Sánchez, MJ
  • Thomas, S
  • Allchurch, E
  • Burgess, P
  • Astrom, A
  • Sverkén, A
  • Broberg, A
  • Masson, A
  • Lehoux, C
  • Brabant, P
  • Pate, P
  • Fontaine, L
  • Sebok, A
  • Kuti, T
  • Hegyi, A
  • Maldonado, C
  • Llorente, A
  • García, E
  • von Fircks, H
  • Hallberg, ML
  • Messerer, M
  • Larsson, M
  • Fredriksson, H
  • Adamsson, V
  • Börjesson, I
  • Fernández, L
  • Smillie, L
  • Wills, J
  • Pedrero-Chamizo, R
  • Meléndez, A
  • Valtueña, J
  • Albers, U
  • Benito, PJ
  • Gómez Lorente, JJ
  • Cañada, D
  • Urzanqui, A
  • Torres, RM
  • Navarro, P

publication date

  • January 2018

has subject area