Synthetic routes to the neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging Academic Article uri icon

abstract

  • The potent Y1receptor antagonist, 1229U91 has an unusual cyclic dimer structure. We have developed three new routes to the synthesis of analogues. Such variants, including fluorescent conjugates, show potent Y1antagonism.

authors

  • Mountford, Simon J
  • Liu, Mengjie
  • Zhang, Lei
  • Groenen, Marleen
  • Herzog, Herbert
  • Holliday, Nicholas D
  • Thompson, Philip E

publication date

  • 2014