Synthetic routes to the neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging Academic Article uri icon


  • The potent Y1receptor antagonist, 1229U91 has an unusual cyclic dimer structure. We have developed three new routes to the synthesis of analogues. Such variants, including fluorescent conjugates, show potent Y1antagonism.


  • Mountford, Simon J
  • Liu, Mengjie
  • Zhang, Lei
  • Groenen, Marleen
  • Herzog, Herbert
  • Holliday, Nicholas D
  • Thompson, Philip E

publication date

  • 2014