Spike—nucleocapsid interaction in Semliki Forest virus reconstructed using network antibodies Academic Article uri icon


  • Using in vitro immunization, we have reconstructed three consecutive steps of an idiotype network to show that the nucleocapsid of Semliki Forest virus contains a specific 'receptor' for the cytoplasmic tail of the E2 spike glycoprotein. This interaction could be the basis for the highly selective inclusion of viral glycoproteins--and exclusion of host cell surface proteins--during virus budding.

publication date

  • November 1988

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