Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial Academic Article uri icon

abstract

  • It has yet to be determined whether genotyping at the angiotensin-converting enzyme (ACE) locus is predictive of blood pressure response to an ACE inhibitor.Participants from the African American Study of Kidney Disease and Hypertension trial randomized to the ACE inhibitor ramipril (n = 347) were genotyped at three polymorphisms on ACE, just downstream from the ACE insertion/deletion polymorphism (Ins/Del): G12269A, C17888T, and G20037A. Time to reach target mean arterial pressure (

authors

  • O'Connor, Dennis
  • Bhatnagar, Vibha
  • OʼConnor, Daniel T
  • Schork, Nicholas J
  • Salem, Rany M
  • Nievergelt, Caroline M
  • Rana, Brinda K
  • Smith, Douglas W
  • Bakris, George L
  • Middleton, John P
  • Norris, Keith C
  • Wright, Jackson T
  • Cheek, Deanna
  • Hiremath, Leena
  • Contreras, Gabriel
  • Appel, Lawrence J
  • Lipkowitz, Michael S

publication date

  • October 2007