Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals Academic Article uri icon

abstract

  • Stature is affected by many polymorphisms of small effect in humans 1 . In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes2,3. Here we use data from cattle to compare the genetic architecture of stature to those in humans and dogs. We conducted a meta-analysis for stature using 58,265 cattle from 17 populations with 25.4 million imputed whole-genome sequence variants. Results showed that the genetic architecture of stature in cattle is similar to that in humans, as the lead variants in 163 significantly associated genomic regions (P < 5 × 10-8) explained at most 13.8% of the phenotypic variance. Most of these variants were noncoding, including variants that were also expression quantitative trait loci (eQTLs) and in ChIP-seq peaks. There was significant overlap in loci for stature with humans and dogs, suggesting that a set of common genes regulates body size in mammals.

authors

  • Bouwman, Aniek C
  • Daetwyler, Hans D
  • Chamberlain, Amanda J
  • Ponce, Carla Hurtado
  • Sargolzaei, Mehdi
  • Schenkel, Flavio S
  • Sahana, Goutam
  • Govignon-Gion, Armelle
  • Boitard, Simon
  • Dolezal, Marlies
  • Pausch, Hubert
  • Brøndum, Rasmus F
  • Bowman, Phil J
  • Thomsen, Bo
  • Guldbrandtsen, Bernt
  • Lund, Mogens S
  • Servin, Bertrand
  • Garrick, Dorian J
  • Reecy, James
  • Vilkki, Johanna
  • Bagnato, Alessandro
  • Wang, Min
  • Hoff, Jesse L
  • Schnabel, Robert D
  • Taylor, Jeremy F
  • Vinkhuyzen, Anna AE
  • Panitz, Frank
  • Bendixen, Christian
  • Holm, Lars-Erik
  • Gredler, Birgit
  • Hozé, Chris
  • Boussaha, Mekki
  • Sanchez, Marie-Pierre
  • Rocha, Dominique
  • Capitan, Aurelien
  • Tribout, Thierry
  • Barbat, Anne
  • Croiseau, Pascal
  • Drögemüller, Cord
  • Jagannathan, Vidhya
  • Vander Jagt, Christy
  • Crowley, John J
  • Bieber, Anna
  • Purfield, Deirdre C
  • Berry, Donagh P
  • Emmerling, Reiner
  • Götz, Kay-Uwe
  • Frischknecht, Mirjam
  • Russ, Ingolf
  • Sölkner, Johann
  • Van Tassell, Curtis P
  • Fries, Ruedi
  • Stothard, Paul
  • Veerkamp, Roel F
  • Boichard, Didier
  • Goddard, Mike E
  • Hayes, Ben J

publication date

  • 2018