Molecular cloning and functional characterization of human lymphotactin Academic Article uri icon

abstract

  • We describe the isolation of a cDNA that encodes human lymphotactin (Ltn), a new class of lymphocyte-specific chemokine. Human Ltn shows similarity to some members of the C-C chemokine family but has lost the first and third cysteine residues that are characteristic of the C-C and C-X-C chemokines. Ltn is chemotactic for lymphocytes but not for monocytes, a characteristic that makes it unique among chemokines. In addition, calcium flux desensitization studies indicate that Ltn uses a unique receptor. The human Ltn gene maps to a different chromosome than do the C-C and C-X-C chemokine families. Taken together, these characteristics indicate that Ltn is the first example of a new class of human chemokines with preferential effects on lymphocytes.

authors

  • Kennedy, J
  • Kelner, GS
  • Kleyensteuber, S
  • Schall, TJ
  • Weiss, MC
  • Yssel, H
  • Schneider, PV
  • Cocks, BG
  • Bacon, KB
  • Zlotnik, A

publication date

  • January 1, 1995