The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation Academic Article uri icon


  • Carotta et al. show that the interaction between IRF8 and PU.1 controls the propensity of B cells to undergo class-switch recombination and plasma cell differentiation by concurrently promoting the expression of BCL6 and PAX5 and repressing AID and BLIMP-1.


  • Carotta, Sebastian
  • Willis, Simon N
  • Hasbold, Jhagvaral
  • Inouye, Michael
  • Pang, Swee Heng Milon
  • Emslie, Dianne
  • Light, Amanda
  • Chopin, Michael
  • Shi, Wei
  • Wang, Hongsheng
  • Morse, Herbert C
  • Tarlinton, David M
  • Corcoran, Lynn M
  • Hodgkin, Philip D
  • Nutt, Stephen L

publication date

  • 2014