Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance Academic Article uri icon

abstract

  • T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells resulting from lack of regulatory T cells or an inability to shut down immune responses can lead to inflammation and autoimmune pathology. Here we show that Blimp-1, a transcriptional repressor that is a 'master regulator' of terminal B cell differentiation, was expressed in a subset of antigen-experienced CD4(+) and CD8(+) T cells. Mice reconstituted with fetal liver stem cells expressing a mutant Blimp-1 lacking the DNA-binding domain developed a lethal multiorgan inflammatory disease caused by an accumulation of effector and memory T cells. These data identify Blimp-1 as an essential regulator of T cell homeostasis and suggest that Blimp-1 regulates both B cell and T cell differentiation.

authors

  • Kallies, Axel
  • Hawkins, Edwin D
  • Belz, Gabrielle T
  • Metcalf, Donald
  • Hommel, Mirja
  • Corcoran, Lynn M
  • Hodgkin, Philip D
  • Nutt, Stephen L

publication date

  • May 2006