A Novel Aspochalasin with HIV-1 Integrase Inhibitory Activity from Aspergillus flavipes Academic Article uri icon

abstract

  • A novel aspochalasin, aspochalasin L (1), was isolated from the fermentation broth of a soil-derived fungal culture identified as Aspergillus flavipes (Deuteromycota). Structure elucidation of 1 was accomplished by detailed spectroscopic data analyses and by comparison with related cytochalasins. Aspochalasin L demonstrated activity against HIV integrase with an IC50 of 71.7microM.

authors

  • Rochfort, Simone
  • Ford, Joanne
  • Ovenden, Simon
  • Wan, Soo San
  • George, Samantha
  • Wildman, Howard
  • Tait, R Murray
  • Meurer-Grimes, Barbara
  • Cox, Susan
  • Coates, Jonathan
  • Rhodes, David

publication date

  • April 2005

has subject area