Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40). Academic Article uri icon


  • Recently, we described a murine helper T cell-derived molecule with T cell growth factor activity that is functionally and structurally distinct from IL-2, IL-4, and other known growth factors. This molecule, designated P40, was identified as a glycoprotein capable of supporting antigen-independent growth of certain helper T cell clones. Here, we report the cloning and expression of a cDNA for this new growth factor. The predicted mature protein is a cationic cysteine-rich polypeptide of 14 kD without significant homology to previously sequenced proteins.


  • Van Snick, J
  • Goethals, A
  • Renauld, JC
  • Van Roost, E
  • Uyttenhove, C
  • Rubira, MR
  • Moritz, RL
  • Simpson, RJ

publication date

  • January 1, 1989