SYNTHESIS AND BIOLOGICAL EVALUATION OF N-SALICYLOYL-N-BENZYLTHIOUREA AND 2,2-DIMETHYL-4-OXO-6-METHOXYBENZO-1,3-DIOXIN Academic Article uri icon

abstract

  • The synthesis of N-salicyloyl-N-benzyl-thiourea and 2,2-dimethyl-4-oxo-6-methoxy-benzo-1,3-dioxin are described. They were studied for their antiviral, antiproliferative and antimicrobial activities in vitro. N-salicyloyl-N-benzyl-thiourea exhibited significant activity against Gram-positive bacteria and against influenza viruses types A/Philippine/H3N2, A/Chilli/H1N1 and B/Paraha, as well as against K562 cell proliferation. By contrast, no such activity was demonstrated by 2,2-dimethyl-4-oxo-6-methoxy-benzo-1,3-dioxin.

publication date

  • May 1, 1991