One-step radiosynthesis of 4-nitrophenyl 2-[ 18 F]fluoropropionate ([ 18 F]NFP); improved preparation of radiolabeled peptides for PET imaging Academic Article uri icon

abstract

  • The versatile (18) F-labeled prosthetic group, 4-nitrophenyl 2-[(18) F]fluoropropionate ([(18) F]NFP), was synthesized in a single step in 45 min from 4-nitrophenyl 2-bromopropionate, with a decay corrected radiochemical yield of 26.2% ± 2.2%. Employing this improved synthesis of [(18) F]NFP, [(18) F]GalactoRGD - the current 'gold standard' tracer for imaging the expression of αV β3 integrin - was prepared with high specific activity in 90 min and 20% decay corrected radiochemical yield from [(18) F]fluoride.

authors

  • Haskali, Mohammad B
  • Roselt, Peter D
  • Karas, John A
  • Noonan, Wayne
  • Wichmann, Christian W
  • Katsifis, Andrew
  • Hicks, Rodney J
  • Hutton, Craig A

publication date

  • 2013