Ex Vivo Hematopoietic Progenitor Cell Expansion Academic Article uri icon

abstract

  • The ability to culture and expand hematopoietic progenitor cells ex vivo has major implications for both bone marrow and stem cell support following marrow ablative or subablative high-dose therapy and for improving the efficiency of retroviral transfection in gene marking and gene therapy. This review focuses on methods for the generation of myeloid progenitor and post-progenitor cells from peripheral blood stem cell collections, with particular emphasis on the characterization of these cells and practical issues associated with their expansion.

authors

  • Haylock, DN
  • Makino, S
  • Dowse, TL
  • Trimboli, S
  • Niutta, S
  • To, LB
  • Juttner, CA
  • Simmons, PJ

publication date

  • December 1994