Sugar or fat?—metabolic requirements for immunity to viral infections Academic Article uri icon

abstract

  • The realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogramming through the use of glycolysis and fatty-acid oxidation (sugar or fat) regulates the capacity of immune cells to mount robust and effective immune responses. We will also discuss how fine-tuning sugar and fat metabolism may be exploited as a novel immunotherapeutic strategy to fight viral infections or improve vaccine efficacy.

authors

  • Shehata, Hesham M
  • Murphy, Andrew J
  • Lee, Man kit Sam
  • Gardiner, Clair M
  • Crowe, Suzanne M
  • Sanjabi, Shomyseh
  • Finlay, David K
  • Palmer, Clovis Steve

publication date

  • 2017