NF-κB inhibitory activity of compounds isolated from Cantharellus cibarius Academic Article uri icon

abstract

  • The inhibitory activities of the extracts of Cantharellus cibarius and isolated compounds were investigated in an enzyme-based ELISA NF-kappaB assay. Of the tested compounds, ergosterol, ergosterol peroxide and cerevisterol were noted to have the most potent inhibition of NF-kappaB activation. The ability of the active metabolites to inhibit the NF-kappaB translocation from the cytoplasm to the nucleus was assessed using a cell-based NF-kappaB assay. The isolated compounds were elucidated through the analysis of various spectroscopic methods.

authors

  • Kim, Jeong Ah
  • Tay, David
  • Blanco, Esperanza Carcache de

publication date

  • August 2008