Inhibiting Protein-Protein Interactions as an Emerging Paradigm for Drug Discovery Academic Article uri icon

abstract

  • Association of proteins into homo- and hetero-oligomers plays an important role in a plethora of biological phenomena. Inhibition of these interactions is increasingly recognized as a valuable new direction in drug design. In this mini-review we consider inhibition of protein misfolding and aggregation, molecules that disrupt enzyme quaternary structure, and signaling inhibitors, as emerging drugs.

publication date

  • February 1, 2007