Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens? Academic Article uri icon

abstract

  • Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and an important antibiotic target. The specificity of a range of heterocyclic product analogues against DHDPS from three pathogenic species, Bacillus anthracis, Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus, and the evolutionarily related N-acetylneuraminate lyase, has been determined. The results suggest that the development of species-specific inhibitors of DHDPS as potential antibacterials is achievable.

authors

  • Mitsakos, Voula
  • Dobson, Renwick CJ
  • Pearce, F Grant
  • Devenish, Sean R
  • Evans, Genevieve L
  • Burgess, Benjamin R
  • Perugini, Matthew A
  • Gerrard, Juliet A
  • Hutton, Craig A

publication date

  • January 2008