The Acidic Nature of the CcmG Redox-Active Center Is Important for Cytochrome c Maturation in Escherichia coli Academic Article uri icon

abstract

  • Cytochrome c biogenesis in Escherichia coli is a complex process requiring at least eight genes (ccmABCDEFGH). One of these genes, ccmG, encodes a thioredoxin-like protein with unusually specific redox activity. Here, we investigate the basis for CcmG function and demonstrate the importance of acidic residues surrounding the redox-active center.

authors

  • Edeling, MA
  • Ahuja, U
  • Heras, B
  • Thony-Meyer, L
  • Martin, JL

publication date

  • June 15, 2004