The Acidic Nature of the CcmG Redox-Active Center Is Important for Cytochrome c Maturation in Escherichia coli Academic Article uri icon


  • ABSTRACT Cytochrome c biogenesis in Escherichia coli is a complex process requiring at least eight genes (ccmABCDEFGH). One of these genes, ccmG, encodes a thioredoxin-like protein with unusually specific redox activity. Here, we investigate the basis for CcmG function and demonstrate the importance of acidic residues surrounding the redox-active center.


  • Edeling, Melissa A
  • Ahuja, Umesh
  • Heras, Begoña
  • Thöny-Meyer, Linda
  • Martin, Jennifer L

publication date

  • June 15, 2004