DSB proteins and bacterial pathogenicity Academic Article uri icon


  • If DNA is the information of life, then proteins are the machines of life--but they must be assembled and correctly folded to function. A key step in the protein-folding pathway is the introduction of disulphide bonds between cysteine residues in a process called oxidative protein folding. Many bacteria use an oxidative protein-folding machinery to assemble proteins that are essential for cell integrity and to produce virulence factors. Although our current knowledge of this machinery stems largely from Escherichia coli K-12, this view must now be adjusted to encompass the wider range of disulphide catalytic systems present in bacteria.


  • Heras, Begoña
  • Shouldice, Stephen R
  • Totsika, Makrina
  • Scanlon, Martin J
  • Schembri, Mark A
  • Martin, Jennifer L

publication date

  • March 2009