Seafood consumption, omega-3 fatty acids intake, and life-time prevalence of depression in the PREDIMED-plus trial Academic Article uri icon

abstract

  • BACKGROUND:The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (ω-3 PUFA) intake, and depression prevalence. METHODS:Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and ω-3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and ω-3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) ω-3 PUFA intake and depressive symptoms. RESULTS:Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63⁻0.94), 0.71 (0.58⁻0.87), and 0.78 (0.64⁻0.96), respectively, and p for trend = 0.759. Moderate intake of total LC ω-3 PUFA (approximately 0.5⁻1 g/day) was significantly associated with a lower prevalence of depression. CONCLUSION:In our study, moderate fish and LC ω-3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.

authors

  • Sánchez-Villegas, A
  • Álvarez-Pérez, J
  • Toledo, E
  • Salas-Salvadó, J
  • Ortega-Azorín, C
  • Zomeño, MD
  • Vioque, J
  • Martínez, JA
  • Romaguera, D
  • Pérez-López, J
  • López-Miranda, J
  • Estruch, R
  • Bueno-Cavanillas, A
  • Arós, F
  • Tur, JA
  • Tinahones, FJ
  • Lecea, O
  • Martín, V
  • Ortega-Calvo, M
  • Vázquez, C
  • Pintó, X
  • Vidal, J
  • Daimiel, L
  • Delgado-Rodríguez, M
  • Matía, P
  • Corella, D
  • Díaz-López, A
  • Babio, N
  • Muñoz, MÁ
  • Fitó, M
  • de la Hera, MG
  • Abete, I
  • García-Rios, A
  • Ros, E
  • Ruíz-Canela, M
  • Martinez-Gonzalez, Miguel A
  • Izquierdo, M
  • Serra-Majem, L

publication date

  • 2018