C-terminal peptides modelling constitutive PrPC processing demonstrate ameliorated toxicity predisposition consequent to α-cleavage Academic Article uri icon

abstract

  • C-terminal fragments generated through α- and β-cleavage of PrPC appear to harbour different pathogenic potential for host cells. Most significantly, α-cleavage produces a C-terminal fragment that is resistant to folding into soluble β-strand-rich toxic isoforms.

authors

  • Johanssen, VA
  • Johanssen, T
  • Masters, CL
  • Hill, AF
  • Barnham, KJ
  • Collins, SJ

publication date

  • 2014