Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles Academic Article uri icon

abstract

  • Cell-cell communication is an important mechanism for information exchange promoting cell survival for the control of features such as population density and differentiation. We determined that Plasmodium falciparum-infected red blood cells directly communicate between parasites within a population using exosome-like vesicles that are capable of delivering genes. Importantly, communication via exosome-like vesicles promotes differentiation to sexual forms at a rate that suggests that signaling is involved. Furthermore, we have identified a P. falciparum protein, PfPTP2, that plays a key role in efficient communication. This study reveals a previously unidentified pathway of P. falciparum biology critical for survival in the host and transmission to mosquitoes. This identifies a pathway for the development of agents to block parasite transmission from the human host to the mosquito.

authors

  • Regev-Rudzki, N
  • Wilson, DW
  • Carvalho, TG
  • Sisquella, X
  • Coleman, BM
  • Rug, M
  • Bursac, D
  • Angrisano, F
  • Gee, M
  • Hill, AF
  • Baum, J
  • Cowman, AF

publication date

  • 2013

published in