Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL Academic Article uri icon

abstract

  • The crystal structure and mutagenesis studies of human MLKL, an essential necroptosis pathway molecular switch, provide insights into how pseudokinase domains accomplish nucleotide binding despite lacking the conventional ATP-binding/catalytic motifs typical of active protein kinases.

authors

  • Murphy, JM
  • Lucet, IS
  • Hildebrand, JM
  • Tanzer, MC
  • Young, SN
  • Sharma, P
  • Lessene, G
  • Alexander, WS
  • Babon, JJ
  • Silke, J
  • Czabotar, PE

publication date

  • 2014

has subject area