The present study investigated the relationship between social comparison processes and depressive symptoms in 36 participants (34 males and two females) aged 10 to 16 years with Asperger syndrome. Participants completed the Social Comparison Scale and the Children's Depression Inventory. Depressive symptoms were significantly correlated with the SCS (r = 0.52, p = 0.001), specifically perceived group membership (r = 0.56, p < 0.001). A regression analysis revealed that perceived group membership significantly and independently predicted depression scores (beta= 0.56, p = 0.002). It is suggested social comparison is a salient factor related to depressive symptoms in this group, and interventions involving adolescents with AS should therefore address this factor.