Non-invasive assessment of dorsiflexor muscle function in mice Academic Article uri icon

abstract

  • Assessment of skeletal muscle contractile function is an important measurement for both clinical and research purposes. Numerous conditions can negatively affect skeletal muscle. This can result in a loss of muscle mass (atrophy) and/or loss of muscle quality (reduced force per unit of muscle mass), both of which are prevalent in chronic disease, muscle-specific disease, immobilization, and aging (sarcopenia). Skeletal muscle function in animals can be evaluated by a range of different tests. All tests have limitations related to the physiological testing environment, and the selection of a specific test often depends on the nature of the experiments. Here, we describe an in vivo, non-invasive technique involving a helpful and easy assessment of force frequency-curve (FFC) in mice that can be performed on the same animal over time. This permits monitoring of disease progression and/or efficacy of a potential therapeutic treatment.

authors

  • Gerlinger-Romero, Frederico
  • Addinsall, Alex B
  • Lovering, Richard M
  • Foletta, Victoria C
  • Van Der Poel, Chris
  • Della-Gatta, Paul A
  • Russell, Aaron P

publication date

  • 2019