Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8+ T cells Academic Article uri icon

abstract

  • The avian origin A/H7N9 influenza virus causes high admission rates (>99%) and mortality (>30%), with ultimately favourable outcomes ranging from rapid recovery to prolonged hospitalization. Using a multicolour assay for monitoring adaptive and innate immunity, here we dissect the kinetic emergence of different effector mechanisms across the spectrum of H7N9 disease and recovery. We find that a diversity of response mechanisms contribute to resolution and survival. Patients discharged within 2-3 weeks have early prominent H7N9-specific CD8(+) T-cell responses, while individuals with prolonged hospital stays have late recruitment of CD8(+)/CD4(+) T cells and antibodies simultaneously (recovery by week 4), augmented even later by prominent NK cell responses (recovery >30 days). In contrast, those who succumbed have minimal influenza-specific immunity and little evidence of T-cell activation. Our study illustrates the importance of robust CD8(+) T-cell memory for protection against severe influenza disease caused by newly emerging influenza A viruses.

authors

  • Wang, Zhongfang
  • Wan, Yanmin
  • Qiu, Chenli
  • Quiñones-Parra, Sergio
  • Zhu, Zhaoqin
  • Loh, Liyen
  • Tian, Di
  • Ren, Yanqin
  • Hu, Yunwen
  • Zhang, Xiaoyan
  • Thomas, Paul G
  • Inouye, Michael
  • Doherty, Peter C
  • Kedzierska, Katherine
  • Xu, Jianqing

publication date

  • 2015