A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 Academic Article uri icon

abstract

  • We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.

authors

  • van Heel, David A
  • Franke, Lude
  • Hunt, Karen A
  • Gwilliam, Rhian
  • Zhernakova, Alexandra
  • Inouye, Mike
  • Wapenaar, Martin C
  • Barnardo, Martin CNM
  • Bethel, Graeme
  • Holmes, Geoffrey KT
  • Feighery, Con
  • Jewell, Derek
  • Kelleher, Dermot
  • Kumar, Parveen
  • Travis, Simon
  • Walters, Julian RF
  • Sanders, David S
  • Howdle, Peter
  • Swift, Jill
  • Playford, Raymond J
  • McLaren, William M
  • Mearin, M Luisa
  • Mulder, Chris J
  • McManus, Ross
  • McGinnis, Ralph
  • Cardon, Lon R
  • Deloukas, Panos
  • Wijmenga, Cisca

publication date

  • July 2007