A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium Academic Article uri icon

abstract

  • To identify the susceptibility gene in hand osteoarthritis (OA) the authors used a two-stage approach genome-wide association study using two discovery samples (the TwinsUK cohort and the Rotterdam discovery subset; a total of 1804 subjects) and four replication samples (the Chingford Study, the Chuvasha Skeletal Aging Study, the Rotterdam replication subset and the Genetics, Arthrosis, and Progression (GARP) Study; a total of 3266 people). Five single-nucleotide polymorphisms (SNPs) had a likelihood of association with hand OA in the discovery stage and one of them (rs716508), was successfully confirmed in the replication stage (meta-analysis p = 1.81x10(-5)). The C allele conferred a reduced risk of 33% to 41% using a case-control definition. The SNP is located in intron 1 of the A2BP1 gene. This study also found that the same allele of the SNP significantly reduced bone density at both the hip and spine (p<0.01), suggesting the potential mechanism of the gene in hand OA might be via effects on subchondral bone. The authors' findings provide a potential new insight into genetic mechanisms in the development of hand OA.

authors

  • Zhai, G
  • van Meurs, JBJ
  • Livshits, G
  • Meulenbelt, I
  • Valdes, AM
  • Soranzo, N
  • Hart, D
  • Zhang, F
  • Kato, BS
  • Richards, JB
  • Williams, FMK
  • Inouye, M
  • Kloppenburg, M
  • Deloukas, P
  • Slagboom, E
  • Uitterlinden, A
  • Spector, TD

publication date

  • September 1, 2009