Hepatitis C has reached epidemic proportions in Australia. Because of its association with injecting drug use, which is a main transmission mode, hepatitis C is a highly stigmatising health condition. In fact, the stigma attached to hepatitis C means hepatitis C is not just a medical diagnosis, but also a social diagnosis. The limited available research indicates hepatitis C-related discrimination is most likely to occur in health care settings. A strategic and evidenced-based approach is required to combat the social impact of hepatitis C.