Electron spectroscopic imaging of encapsidated DNA in vaccinia virus Academic Article uri icon


  • We have used electron spectroscopic imaging to locate the phosphorus in vaccinia DNA in situ in unstained, ultrathin sections of virions. The phosphorus of the DNA backbone appeared to form a halo on the core periphery surrounding a phosphorus-impoverished central element. These results constrain models for how DNA could be packaged into mature vaccinia particles.


  • Harauz, G
  • Evans, DH
  • Beniac, DR
  • Arsenault, AL
  • Rutherford, B
  • Ottensmeyer, FP

publication date

  • October 1995