Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma Academic Article uri icon

abstract

  • Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10(-8) for rs6445055), two on chromosome 9 (P = 2.80 × 10(-11) for rs2472493 near ABCA1 and P = 6.39 × 10(-11) for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10(-11) for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG.

authors

  • Hysi, Pirro G
  • Cheng, Ching-Yu
  • Springelkamp, Henriët
  • Macgregor, Stuart
  • Bailey, Jessica N Cooke
  • Wojciechowski, Robert
  • Vitart, Veronique
  • Nag, Abhishek
  • Hewitt, Alex W
  • Höhn, René
  • Venturini, Cristina
  • Mirshahi, Alireza
  • Ramdas, Wishal D
  • Thorleifsson, Gudmar
  • Vithana, Eranga
  • Khor, Chiea-Chuen
  • Stefansson, Arni B
  • Liao, Jiemin
  • Haines, Jonathan L
  • Amin, Najaf
  • Wang, Ya Xing
  • Wild, Philipp S
  • Ozel, Ayse B
  • Li, Jun Z
  • Fleck, Brian W
  • Zeller, Tanja
  • Staffieri, Sandra E
  • Teo, Yik-Ying
  • Cuellar-Partida, Gabriel
  • Luo, Xiaoyan
  • Allingham, R Rand
  • Richards, Julia E
  • Senft, Andrea
  • Karssen, Lennart C
  • Zheng, Yingfeng
  • Bellenguez, Céline
  • Xu, Liang
  • Iglesias, Adriana I
  • Wilson, James F
  • Kang, Jae H
  • van Leeuwen, Elisabeth M
  • Jonsson, Vesteinn
  • Thorsteinsdottir, Unnur
  • Despriet, Dominiek DG
  • Ennis, Sarah
  • Moroi, Sayoko E
  • Martin, Nicholas G
  • Jansonius, Nomdo M
  • Yazar, Seyhan
  • Tai, E-Shyong
  • Amouyel, Philippe
  • Kirwan, James
  • van Koolwijk, Leonieke ME
  • Hauser, Michael A
  • Jonasson, Fridbert
  • Leo, Paul
  • Loomis, Stephanie J
  • Fogarty, Rhys
  • Rivadeneira, Fernando
  • Kearns, Lisa
  • Lackner, Karl J
  • de Jong, Paulus TVM
  • Simpson, Claire L
  • Pennell, Craig E
  • Oostra, Ben A
  • Uitterlinden, André G
  • Saw, Seang-Mei
  • Lotery, Andrew J
  • Bailey-Wilson, Joan E
  • Hofman, Albert
  • Vingerling, Johannes R
  • Maubaret, Cécilia
  • Pfeiffer, Norbert
  • Wolfs, Roger CW
  • Lemij, Hans G
  • Young, Terri L
  • Pasquale, Louis R
  • Delcourt, Cécile
  • Spector, Timothy D
  • Klaver, Caroline CW
  • Small, Kerrin S
  • Burdon, Kathryn P
  • Stefansson, Kari
  • Wong, Tien-Yin
  • Paul, Mitchell
  • Wang, Jie Jin
  • Rochtchina, Elena
  • Attia, John
  • Scott, Rodney
  • Holliday, Elizabeth
  • Wong, Tien Yin
  • Baird, Paul M
  • Xie, Jing
  • Inouye, Michael
  • Viswanath, Ananth
  • Sim, Xueling
  • Allingham, R Rand
  • Brillian, Murray
  • Budenz, Donald
  • Cooke Bailey, Jessica N
  • Christen, William G
  • Fingert, John
  • Friedman, David S
  • Gaasterland, Douglas
  • Gaasterland, Terry
  • Haines, Jonathan L
  • Hauser, Michael A
  • Kang, Jae Hee
  • Kraft, Peter
  • Lee, Richard K
  • Lichter, Paul A
  • Liu, Yutao
  • Loomis, Stephanie J
  • Moroi, Sayoko E
  • Pasquale, Louis R
  • Pericak-Vance, Margaret A
  • Realini, Anthony
  • Richards, Julia E
  • Schuman, Joel S
  • Scott, William K
  • Singh, Kuldev
  • Sit, Arthur J
  • Vollrath, Douglas
  • Weinreb, Robert N
  • Wiggs, Janey L
  • Wollstein, Gadi
  • Zack, Donald J
  • Zhang, Kang
  • Donnelly, Peter
  • Barroso, Ines
  • Blackwell, Jenefer M
  • Bramon, Elvira
  • Brown, Matthew A
  • Casas, Juan P
  • Corvin, Aiden
  • Deloukas, Panos
  • Duncanson, Audrey
  • Jankowski, Janusz
  • Markus, Hugh S
  • Mathew, Christopher G
  • Palmer, Colin NA
  • Plomin, Robert
  • Rautanen, Anna
  • Sawcer, Stephen J
  • Trembath, Richard C
  • Viswanathan, Ananth C
  • Wood, Nicholas W
  • Spencer, Chris CA
  • Band, Gavin
  • Bellenguez, Celine
  • Freeman, Colin
  • Hellenthal, Garrett
  • Giannoulatou, Eleni
  • Pirinen, Matti
  • Pearson, Richard
  • Strange, Amy
  • Su, Zhan
  • Vukcevic, Damjan
  • Donnelly, Peter
  • Langford, Cordelia
  • Hunt, Sarah E
  • Edkins, Sarah
  • Gwilliam, Rhian
  • Blackburn, Hannah
  • Bumpstead, Suzannah J
  • Dronov, Serge
  • Gillman, Matthew
  • Gray, Emma
  • Hammond, Naomi
  • Jayakumar, Alagurevathi
  • McCann, Owen T
  • Liddle, Jennifer
  • Potter, Simon C
  • Ravindrarajah, Radhi
  • Ricketts, Michelle
  • Waller, Matthew
  • Weston, Paul
  • Widaa, Sara
  • Whittaker, Pamela
  • Barroso, Ines
  • Deloukas, Panos
  • Viswanathan, Ananth
  • Mackey, David A
  • Craig, Jamie E
  • Wiggs, Janey L
  • van Duijn, Cornelia M
  • Hammond, Christopher J
  • Aung, Tin

publication date

  • 2014

has subject area