AIMS: To determine the potential uses and limitations of 3DCT craniofacial imaging in contemporary clinical practice. METHODS: The relevant historical and contemporary literature was reviewed. RESULTS: There would seem to be many potential uses for 3D-CT craniofacial imaging in clinical practice. Significant limitations may, however, relate to the availability and cost of such imaging and the delivered radiation dose. CONCLUSIONS: With continued research and development, the use of such 3D-CT craniofacial imaging techniques may become appropriate for future orthodontic and clinical diagnostic applications.