Growth Hormone Deficiency Is Frequent After Recent Stroke Academic Article uri icon


  • Introduction: The incidence of pituitary dysfunction after severe ischemic stroke is unknown, however given the increasing attention to pituitary dysfunction after neurological injuries such as traumatic brain injury, this may represent a novel area of research in stroke. Methods: We perform an arginine and human growth hormone releasing hormone challenge on ischemic stroke patients within a week of symptom onset. Results: Over the study period, 13 patients were successfully tested within a week of stroke (baseline NIHSS 10, range 7-16). Overall, 9(69%) patients had a poor response, with 7(54%) of these patients meeting the criteria for had human growth hormone deficiency. Other measures of pituitary function were within normal ranges. Conclusion: After major ischemic stroke, low GH levels are common and may play a role in stroke recovery.


  • Lillicrap, T
  • Garcia-Esperon, C
  • Walker, FR
  • Ong, LK
  • Nilsson, Michael
  • Spratt, N
  • Levi, CR
  • Parsons, M
  • Isgaard, J
  • Bivard, A

publication date

  • 2018