Outcomes following front-line chemotherapy in peripheral T-cell lymphoma: 10-year experience at The Royal Marsden and The Christie Hospital Academic Article uri icon

abstract

  • We evaluated the outcomes for patients with peripheral T-cell lymphoma (PTCL) undergoing front-line chemotherapy at our institutions between 2002 and 2012. One hundred and fifty-six patients were eligible, comprising PTCL not otherwise specified (NOS) (n = 50, 32.0%), angioimmunoblastic T-cell lymphoma (AITL) (n = 44, 28.2%), anaplastic large-cell lymphoma (ALCL) ALK negative (n = 23, 14.7%), ALCL ALK positive (n = 16, 10.3%), and other (n = 23, 14.7%). Most patients received CHOP (66.0%) and 13.0% received an autologous hematopoietic progenitor cell transplant (HPCT). With a median follow-up of 63.4 months, 5-year overall survival (OS) and progression-free survival (PFS) was 38.8% and 19.8% respectively. Independent risk factors for inferior OS were age >60 years, International Prognostic Index (IPI) ≥ 2 and lack of complete response to induction. When responding patients were compared by receipt of an autologous HPCT versus not, HPCT was associated with improved PFS (p = .001) and OS (p = .046) and remained significant for PFS in multivariate analysis suggesting a possible therapeutic benefit.

authors

  • Gleeson, Mary
  • Peckitt, Clare
  • Cunningham, David
  • Gibb, Adam
  • Hawkes, Eliza A
  • Back, Morgan
  • Yasar, Binnaz
  • Foley, Kate
  • Lee, Rebecca
  • Dash, Joanna
  • Johnson, Hannah
  • O’Hara, Catherine
  • Wotherspoon, Andrew
  • Attygalle, Ayoma
  • Menasce, Lia
  • Shenjere, Patrick
  • Potter, Mike
  • Ethell, Mark E
  • Dearden, Claire
  • Radford, John
  • Chau, Ian
  • Linton, Kim

publication date

  • 2018

has subject area