Sleep duration is inversely associated with serum uric acid concentrations and uric acid to creatinine ratio in an elderly Mediterranean population at high cardiovascular risk Academic Article uri icon

abstract

  • The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndrome in the (Prevención con Dieta Mediterránea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations (β = −0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio (β = −0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio.

authors

  • Papandreou, Christopher
  • Babio, Nancy
  • Díaz-López, Andrés
  • Martinez-Gonzalez, Miguel A
  • Becerra-Tomas, Nerea
  • Corella, Dolores
  • Schröder, Helmut
  • Romaguera, Dora
  • Vioque, Jesús
  • Alonso-Gómez, Ángel
  • Wärnberg, Julia
  • Martínez, Alfredo
  • Serra-Majem, Lluís
  • Estruch, Ramon
  • Muñoz-Garach, Araceli
  • Lapetra, José
  • Pintó, Xavier
  • Tur, Josep
  • Garcia-Rios, Antonio
  • Bueno-Cavanillas, Aurora
  • Delgado-Rodríguez, Miguel
  • Matía-Martín, Pilar
  • Daimiel, Lidia
  • Martín-Sánchez, Vicente
  • Vidal, Josep
  • Vázquez, Clotilde
  • Ros, Emilio
  • Ruiz-Canela, Miguel
  • Bulló, Mónica
  • Sorli, Jose
  • Quifer, Mireia
  • Colom, Antoni
  • Oncina-Canovas, Alejandro
  • Tojal-Sierra, Lucas
  • Barón-López, Javier
  • Pérez-Farinós, Napoleón
  • Abete, Itziar
  • Sanchez-Villegas, Almudena
  • Casas, Rosa
  • Fernández-Garcia, José
  • Santos-Lozano, José
  • Corbella, Emili
  • del M. Bibiloni, Maria
  • Diez-Espino, Javier
  • Asensio, Eva
  • Torras, Laura
  • Morey, Marga
  • Compañ-Gabucio, Laura
  • Salaverria-Lete, Itziar
  • Cenoz-Osinaga, Juan
  • Castañer, Olga
  • Salas-Salvadó, Jordi

publication date

  • 2019