Reversible and formaldehyde-mediated covalent binding of a bis-amino mitoxantrone analogue to DNA Academic Article uri icon

abstract

  • The ability of the anthracenedione anticancer drug WEHI-150 to form covalent adducts with DNA, after activation by formaldehyde, has been studied by mass spectrometry, HPLC and NMR spectroscopy.

publication date

  • 2016