Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets Academic Article uri icon

abstract

  • Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.

authors

  • Gunawan, Sylvia T
  • Kempe, Kristian
  • Bonnard, Thomas
  • Cui, Jiwei
  • Alt, Karen
  • Law, Lok S
  • Wang, Xiaowei
  • Westein, Erik
  • Such, Georgina K
  • Peter, Karlheinz
  • Hagemeyer, Christoph E
  • Caruso, Frank

publication date

  • 2015