Bio-Click Chemistry: Enzymatic Functionalization of PEGylated Capsules for Targeting Applications Academic Article uri icon

abstract

  • All sorted: The enzyme Sortase A was used to catalyze functionalization of PEGylated capsules with an activation-specific anti-platelet single-chain antibody (scFv). This enzymatic method allows fast, covalent, and site-directed functionalization of delivery vehicles under mild conditions. Activation-specific anti-platelet scFv-coated PEGylated capsules exhibited a high level of selective binding to thrombi, thus suggesting their potential for thrombosis therapy.

authors

  • Leung, Melissa KM
  • Hagemeyer, Christoph E
  • Johnston, Angus PR
  • Gonzales, Catalina
  • Kamphuis, Marloes MJ
  • Ardipradja, Katie
  • Such, Georgina K
  • Peter, Karlheinz
  • Caruso, Frank

publication date

  • July 16, 2012