Isolation of drug-resistant H5N1 virus Academic Article uri icon


  • The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.


  • Le, Q Mai
  • Kiso, Maki
  • Someya, Kazuhiko
  • Sakai, Yuko T
  • Nguyen, T Hien
  • Nguyen, Khan HL
  • Pham, N Dinh
  • Ngyen, Ha H
  • Yamada, Shinya
  • Muramoto, Yukiko
  • Horimoto, Taisuke
  • Takada, Ayato
  • Goto, Hideo
  • Suzuki, Takashi
  • Suzuki, Yasuo
  • Kawaoka, Yoshihiro

publication date

  • October 2005

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