β-Pro⁷Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT₂R in conscious spontaneously hypertensive rats Academic Article uri icon

abstract

  • We have synthesized a highly selective compound that is able to target a protein-binding site [called angiotensin (Ang) II type 2 receptor, AT2R] in the cardiovascular system. This research tool will enhance our ability to stimulate AT2R to produce protective effects against cardiovascular disease.

authors

  • Del Borgo, Mark
  • Wang, Yan
  • Bosnyak, Sanja
  • Khan, Morimer
  • Walters, Pia
  • Spizzo, Iresha
  • Perlmutter, Patrick
  • Hilliard, Lucinda
  • Denton, Kate
  • Aguilar, Marie-Isabel
  • Widdop, Robert E
  • Jones, Emma S

publication date

  • 2015

has subject area