A New Nucleophilic Addition/Ring-Closure Sequence. Enantioselective Synthesis of 3-Deoxy-8-oxatropanes Academic Article uri icon


  • [reaction: see text] A study of new nucleophilic addition/ring-closure (NARC) sequences has resulted in the development of a stereoselective synthetic route to 3-deoxy-8-oxatropanes. The new sequences consisted of either a syn or anti aldol addition, employing an omega-alkenoyl sultam, followed by two-step bicyclic ring construction involving, consecutively, ring-closing metathesis and intramolecular oxymercuration.

publication date

  • March 2004