Highly polymorphic repeat marker within the ?-amyloid precursor protein gene Academic Article uri icon


  • We have identified a polymorphic compound dinucleotide repeat sequence in intron 1 of the beta-amyloid precursor protein (APP) gene on chromosome 21. Using polymerase chain reaction (PCR) amplification of the locus, designated APPivs1, we detected 13 alleles in the CEPH family members (heterozygosity = 0.69). Lod score analysis showed complete linkage of the marker to the loci D21S210 and D21221.


  • Zappata, Stefania
  • Petersen, MichaelB
  • K�nig, Ulrich
  • Blaschak, Jillian
  • Chakravarti, Arvinda
  • Tassone, Flora
  • Serra, Angelo
  • Antonarakis, StylianosE
  • Brahe, Christina

publication date

  • January 1994